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One early, simple example, when the people on the Fountain Pen Network in 2016 used Sinaiticus to show that iron gall ink can last without any significant effect on parchment.
> DC Waites
> Look up the Codex Sinaiticus. The original writing was made with a good batch of IG ink and is still hard and black...
Parchment and ink science had to change to account for Sinaiticus.